Preconditioning does not attenuate myocardial stunning.
نویسندگان
چکیده
منابع مشابه
Preconditioning does not attenuate myocardial stunning.
BACKGROUND Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardi...
متن کاملPreconditioning improves energy metabolism during reperfusion but does not attenuate myocardial stunning in porcine hearts.
BACKGROUND It has been reported that a brief period of coronary occlusion and reperfusion slows the rate of ATP depletion during subsequent sustained ischemia as well as limiting infarct size. However, it has not yet been determined whether ischemic preconditioning also has an effect on the functional and metabolic recovery of stunned myocardium. Our study was designed to address this problem. ...
متن کاملLate Preconditioning against Myocardial Stunning
Introduction Conscious pigs underwent a sequence of 10 2-min coronary occlusions, each separated by 2 min of reperfusion, for three consecutive days (days 1, 2, and 3 of stage I). The recovery of systolic wall thickening (WTh) after the 10th reperfusion was markedly improved on days 2 and 3 compared with day 1, indicating that the myocardium had become preconditioned against "stunning." 10 d af...
متن کاملNitric oxide donors attenuate myocardial stunning in conscious rabbits.
Although previous studies suggested that the protection of late preconditioning (PC) against myocardial stunning is mediated by nitric oxide (NO), direct evidence that exogenous administration of NO attenuates myocardial stunning is lacking. Furthermore, although exogenous NO administration was shown to elicit a late PC phase, it is unknown whether NO donors also induce an early PC phase. There...
متن کاملDoes myocardial stunning contribute to infarct size limitation by ischemic preconditioning?
BACKGROUND The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'PC), one cycle of 5-minute ischemia by 5-minute reperfusion (5'PC1), and two ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1992
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.85.6.2247